Improvement of the bioavailability of curcumin by a supersaturatable self nanoemulsifying drug delivery system with incorporation of a hydrophilic polymer: <i>in vitro</i> and <i>in vivo</i> characterisation

Abstract Objectives The current study was focused on preparing curcumin (CUR) supersaturated self-nano-emulsion (PI-CUR-SNEDDS) using hydrophilic polymer and to the influence of precipitation inhibitor physicochemical biopharmaceutical properties PI-CUR-SNEDDS. Methods PI-CUR-SNEDDS were prepared in order maintain supersaturation CUR nano-emulsion solution, artificial gastrointestinal fluid (AGF), precipitates formed, characterised by vitro dispersion tests, intestinal absorption vivo pharmacokinetic compared with CUR-SNEDDS. Key findings 2% hydroxypropyl methylcellulose 55–60 (HPMC55-60) as (PI) significantly improved viscosity, physical stability CUR’s equilibrium solubility nanoemulsion. HPMC55-60 interact AGF through intermolecular interactions, form hydrogen bonds, produce amorphous precipitates. Compared CUR-SNEDDS, proportion phase increased about 3-fold, apparent permeability coefficient (Papp) duodenum, jejunum, ileum, colon 2.30, 3.65, 1.54 2.08-fold, respectively, area under plasma concentration-time curve0-12h also 3.50-fold. Conclusions Our results suggested that maintained state forming bonds CUR, increasing solution’s viscosity drug solubilisation, thus improving bioavailability CUR.